Congres
programma

• Hoe kijkt de zorgverzekeraar aan tegen praktijkvariatie?
• Hoe kijkt buitenwereld naar implementatie zorg en goed gebruik geneesmiddelen?
• Wat zijn de getallen voor de Reumatologie uit ZE&GG, hoe ziet de praktijk variatie eruit?
• Discussie in groepen over verschillende onderwerpen
• Terugrapportage vanuit de discussiegroepen

• Verdiepende presentatie: Vroege RA
• Intervention with methotrexate in arthralgia at risk for rheumatoid arthritis to reduce the development of persistent arthritis and its disease burden (TREAT EARLIER): a double-blind, randomized, placebo-controlled trial
• Pharmacokinetic boosting to enable a once-daily reduced dose of tofacitinib in patients with rheumatoid arthritis and psoriatic arthritis
• Long-term Effectiveness of Ultra-Low Doses of Rituximab in Rheumatoid Arthritis
• Non-medical switching from tocilizumab to sarilumab in rheumatoid arthritis patients with low disease activity

• Verdiepende presentatie: Immune cell checkpoints in systemic autoimmune diseases
• Targeting T cell abnormalities in systemic sclerosis with specific cytolytic treatment
• Increased maturity of circulating antibody-secreting cells is associated with disease features in primary Sjögren’s syndrome
• IgG/IgM autoantibody ratios do not relate to progression from incomplete systemic lupus erythematosus to systemic lupus erythematosus
• Extrathymic Autoimmune Regulator (AIRE) expressing cells in primary Sjögren’s Syndrome.

13.00-13.20: PRO’s: Van Wetenschap naar Praktijk – mogelijk gemaakt door Lilly

13.30-13.50: Hoe voorkom jij dat jouw reumapatiënten uitvallen op de arbeidsmarkt? – mogelijk gemaakt door AbbVie B.V. 

• Gecompliceerde jichttophi: mes of medicatie? Gecompliceerde jichttophi: mes of medicatie?
• Nut van DNA techniek bij kweek negatieve artritis
• Prednison als premedicatie bij rituximab : intraveneus of oraal?

• Verdiepende presentatie: glucocorticoïden
• Individual patient data meta-analysis on continued use of glucocorticoids after their use as bridging therapy in patients with rheumatoid arthritis
• Concomitant prednisone may alleviate methotrexate side-effects in rheumatoid arthritis patients.
• CAT: “Slowly but surely” – Tocilizumab in de behandeling van refractaire polymyalgia rheumatica;

• Verdiepende presentatie: Man – vrouw verschillen / gender differences
• What is the effect of methotrexate on semen parameters? Results of a prospective cohort study (iFAME-MTX).
• Reported congenital malformations after exposure to non-TNF-α inhibitors: a retrospective comparative study in Eudravigilance database
• Immune cell imbalances in placentas of systemic lupus erythematosus and primary Sjögren's syndrome patients
• Dilemma of Belimumab therapy (dis)continuation during pregnancy: results of a retrospective study in EudraVigilance

• The comparison of ultrasound, [18F]fluorodeoxyglucose-positron emission tomography/computed tomography and magnetic resonance imaging: early diagnostics in giant cell arteritis
• Hand and foot MRI in contemporary undifferentiated arthritis: in which patients is MRI valuable to detect rheumatoid arthritis early? – a large prospective study
• Towards a simplified fluid-sensitive MRI protocol in small joints of the hand in early arthritis patients: reliability between mDixon and regular FSE fat saturation MRI-sequences
• The comparison of axial [18F]Fluoride uptake on PET-CT and anatomical changes on MRI and X-rays in clinically active ankylosing spondylitis patients
• Interosseous tendon inflammation in the hands: a novel feature of developing rheumatoidarthritis? Results from a large MRI study in clinically suspect arthralgia
• Spinal radiographic progression and its association with progression to ankylosing spondylitis in patients with non-radiographic axial spondyloarthritis.

• Development of a screening algorithm for the early detection of primary antibody deficiencies in primary care
• FRYQ questionnaire distinguishes inflammatory from non-inflammatory disease in newly referred patients
• Delayed referral of female rheumatoid arthritis patients: where are we now? A study spanning three decades
• Development of a Screening Tool for the Detection of Active Psoriatic Arthritis in Psoriasis Patients at the Dermatological Clinic
• Quantification of the treatment usage for hand osteoarthritis population: a literature review and the HOSTAS cohort
• The occurrence of overwhelming fatigue in individuals with knee osteoarthritis: a daily diary study
• Determination and characterization of patient subgroups with different pain progression in hand osteoarthritis
• A proof of principle experiment into the added value of Raman spectroscopy for synovial crystal research
• Health care providers’ perspective on continuation versus temporary interruption of immunomodulatory agents in case of an infection: an interview study
• Multimorbidity status and annual healthcare expenditures of rheumatoid arthritis patients: A Dutch hospital-centered versus population-based comparison

• In vitro characterization of candidate anti-angiogenic agents for therapy and molecular imaging  in rheumatoid arthritis
• Comparison of MTX-polyglutamate accumulation profiles in peripheral blood mononuclear cells and erythrocytes during 6 months MTX-therapy in the Methotrexate Monitoring (MeMo) trial.
• Impact of folylpolyglutamate synthetase mRNA splicing on methotrexate polyglutamylation in polarized macrophages.
• The macrophage mannose receptor CD206 as novel target for M2 macrophages PET imaging in rheumatoid arthritis
• In Rheumatoid Arthritis Inflamed Joints share Dominant Patient-Specific B-Cell Clones
• Functional characterisation of ACPA-producing B cell clones using kinase inhibitors
• No change in serum levels of bone turnover markers corrected for age and gender during the first year of secukinumab treatment in patients with ankylosing spondylitis
• Transmembrane TNF overexpression induces features of spondyloarthritis accompanied with B cell lineage alterations and development of ectopic lymphoid structures in the bone marrow
• Increased expression of B cell receptor signalling genes in patients with ankylosing spondylitis
• Pharmacokinetics of methotrexate polyglutamates in peripheral blood mononuclear cells of RA patients is similar after subcutaneous or oral administration in the Methotrexate Monitoring (MeMo) trial.

• Integrated Safety Analysis Update for Filgotinib in Patients with Moderately to Severely Active Rheumatoid Arthritis Receiving Treatment over a Median of 2.2 Years
• The added value of a predictive biomarker in treat-to-target strategies for Rheumatoid Arthritis: a modelling study.
• Long-term Dynamics of antibody response to adalimumab detected with a drug tolerant assay
• Lipid profile changes from pre-clinical to established rheumatoid arthritis: a 12 years followup pilot study
• Favorable effects of TNF inhibiting therapy on intima media thickness and arterial stiffness progression in rheumatoid arthritis patients: a systematic review and meta-analysis
• Cumulative joint inflammation is associated with local joint damage progression in rheumatoid arthritis despite long-term targeted treatment
• Expression of myxovirus resistance protein A in lupus nephritis
• Proteogenomic analysis of the autoreactive B cell repertoire in blood and tissues of patients with Sjögren’s syndrome.
• Proinflammatory monocytes and macrophages in synovial fluid and bursal tissue of patients with polymyalgia rheumatica: potent producers of IL-6 and GM-CSF
• Patient acceptable symptom state (PASS) in patients with primary Sjögren's syndrome in daily clinical practice
• Patient-reported outcomes to assess dyspnea in connective tissue diseases, interstitial lung disease and pulmonary hypertension, a systematic literature review of measurement properties using COSMIN guidelines

• Immune-related rheumatological adverse events after immune checkpoint inhibitor treatment: an emerging field in need of critical appraisal.
• Rheumatology patients treated with a bDMARD perspective towards therapeutic drug monitoring
• Sex differences in the effectiveness of first-line tumor necrosis factor inhibitors in axial spondyloarthritis; results from fifteen countries in the European Spondyloarthritis (EuroSpA) Research Collaboration Network
• Sex differences in the effectiveness of first-line tumor necrosis factor inhibitors in psoriatic arthritis; results from thirteen countries in the European Spondyloarthritis (EuroSpA) Research Collaboration Network
• In radiographic axial spondyloarthritis spinal mobility measures correlate well with the whole spine CT Syndesmophyte Score (CTSS)
• The prevalence of inflammatory back pain and HLA-B27 in a large population-based cohort in the Netherlands
• Do fatty lesions explain the association between inflammation and new syndesmophytes in patients with radiographic axial spondyloarthritis?
• Axial and peripheral bone formation in psoriatic arthritis patients can be visualized using [18F]Fluoride PET-CT scans
• Patient characteristics and clinical assessments associated with progression from non-radiographic axial spondyloarthritis to ankylosing spondylitis
• Mild psoriasis seems often underdiagnosed in patient with axial spondyloarthritis

Ingrid Lundberg, Karolinska Institute

flower power flyer

Naar keuze 3 kwartier wandelen of hardlopen, of volg een yoga sessie. Een goed en gezond begin van de dag!

• Nederlandse Vereniging voor Reumatologie
• Nederlandse Vereniging voor Health Professionals in de Reumatologie

• Verdiepende presentatie Voeding en Gezondheid
• Cardiovascular disease risk in inflammatory arthritis still elevated in 2021!
• Self-reported physical activity in patients with axSpA: adherence to public health recommendations and association with health status in two Dutch cohorts
• Effect of a Multidisciplinary Lifestyle Program in Patients with Rheumatoid Arthritis: The "Plants for Joints" Randomized Controlled Trial
• Effect of a Multidisciplinary Lifestyle Program on Patients with Metabolic Syndrome-Associated Osteoarthritis: The Plants for Joints Randomized Controlled Trial

• Verdiepende presentatie: eHealth, succesfactoren en valkuilen
• Smartphone-Assisted Patient-Initiated Care Versus Usual care in Patients With Rheumatoid Arthritis and Low Disease Activity: a Randomized Controlled Trial
• Gaming for Adherence to Medication using Ehealth in Rheumatoid arthritis (GAMER) study – a randomised controlled trial
• Observed gender difference in adherence to telemonitoring disease activity in patients with inflammatory arthritis: a prospective cohort study
• Which factors influence patients' preferences for telehealth applications in rheumaticdiseases’? A qualitative study

• Welkom
• De waarde van diagnostiek:
  • Gezondheids-economische evaluatie van diagnostische algoritmes voor axSpA
• De waarde van behandeling:
  • tREACH:  Kosten versus effecten van HCQ, MTX of GC bij vroege reumafactor negatieve RA
  • Gloria: Kosten versus effectiviteit van additioneel lage dosis prednison bij behandeling oudere RA patiënten
• Taperen en andere waardevolle strategieën
• De RECORD richtlijn

• Shared care binnen de kinderreumatologie, nut of noodzaak?
• Multisysteem inflammatoir syndroom in kinderen na COVID-19 infectie

• Severity of SARS-CoV-2 Omicron breakthrough infections in patients with rheumatic immune-mediated inflammatory diseases and healthy controls: data from a prospective cohort study
• Seroconversion after a third dose Coronavirus Disease-19 vaccination is associated with lower rituximab dosage in patients with rheumatoid arthritis
• Early achievement of minimal disease activity in psoriatic arthritis is associated with long-term improvements in quality of life
• One-year Results of the BRIDGE-PMR Study, a Randomized Double-blind Placebo-controlled Trial With Rituximab in Polymyalgia Rheumatica.
• Intercurrent infection as a risk factor for disease flares in patients with systemic lupus erythematosus
• A 10-year journey of caring for patients with systemic sclerosis: follow-up data on disease duration of the Leiden CCISS cohort.

• Association of endothelial to mesenchymal transition and cellular senescence with fibrosis in skin biopsies of systemic sclerosis patients
• Expression of fibroblast activation protein in giant cell arteritis
• Increased neutrophil frequency in lymph nodes of patients with Psoriatic Arthritis
• Single cell RNA sequencing points to a potential role for fibroblasts early in salivary gland dysfunction in primary Sjögren’s syndrome
• AMPA can be detected in saliva, but not in faeces of seropositive RA patients: the AMPA response does not seem to develop in the gut
• Labial and parotid salivary gland histopathology in primary Sjögren’s syndrome

• De focus van onderzoek op de verbetering van het verwijzingsproces van mensen met systemische sclerose naar de paramedische zorg
• De Beweegpoli is een nieuw initiatief van Fysiotherapie Utrecht Oost en de reumatologen van het Diaconessenhuis Utrecht om 1e- en 2e lijnszorg te combineren. Het doel van de Beweegpoli is om de kwaliteit van zorg voor patiënten met reumatische aandoeningen te verbeteren en ze optimaal te assisteren bij het “in beweging komen”. Op de beweegpoli is er oog voor alle hindernissen die de patiënt kan ervaren. Door een snelle kennismaking met de eerstelijnszorg wordt ook de tweedelijnszorg ontlast (juiste zorg op de juiste plek).
• Onderzoek, implementatie en reumanetwerken

• Profound anticoagulant effects of initial antirheumatic treatment with certolizumab-pegol, abatacept, tocilizumab or conventional therapy in patients with early rheumatoid arthritis; a NORD-STAR spin-off study
• Prediction of response to anti-TNF treatment using laboratory biomarkers in rheumatoid arthritis patients: a systematic review.
• The Effect of 8 Years of TNF-α Blocking Therapy on Bone Mineral Density in Patients With Ankylosing Spondylitis
• Treatment decisions in axial spondyloarthritis are more than treat to target
• Drug-related problems reported by patients with rheumatic diseases: An observational study
• Six years treatment with TNF-α inhibitors does not lead to prolonged hypermineralization as assessed by bone turnover markers in patients with ankylosing spondylitis

• Verdiepende presentatie: Economische evaluaties in de reumatologie – de basis
• Recommendations on cost-effective use of biological and targeted synthetic DMARDs in inflammatory arthritis: results from an international Delphi study
• Treat-to-target dose reduction and withdrawal strategy of TNF inhibitors in Psoriatic Arthritis and Axial Spondyloarthritis: a randomized controlled non-inferiority trial
• The association of hand OA with paid an unpaid work impairment and related costs: the HOSTAS cohort
• Clinically suspect arthralgia patients with a low educational attainment have an increased risk to develop inflammatory arthritis

VrijMiQaulity –  Blijf plakken, deze sessie belooft je inzicht in je dagelijks werk!

• Hoe bevorderen onze collega’s hun kwaliteit met kennis van uitkomsten? Lessen uit de cardiologie.
• DQRA – Historische feiten en een doorkijkje naar toekomstige ontwikkelingen die deelnemers wensen
• Een succesvol dashboard waar iedereen wel wat mee kan en wil! Dus.. wat bedreigt ons en hoe lossen we dat op?

• Let’s talk about seks! Inzicht en bespreekbaar maken van seksuele veranderingen bij reuma.
• Inzicht creëren en bespreekbaar maken van seksuele problemen.
• Medicatie: ups en downs door zwangerschap.
• Praktische begeleiding rondom reuma en zwangerschap.

• Cardiovascular risk management in rheumatic patients – past, present and future (plans);
• Gout and the heart: it is not crystal clear!
• Nomen est omen: Janus kinase inhibitors in inflammatory conditions: which face are we looking at?

Paul Iske